Aron H. Blaesi, Henning Richter, Nannaji Saka, Enhancing the bioavailability of sparingly soluble drugs by expandable, solid-solution fibrous dosage forms, International Journal of Pharmaceutics, 2024, under review.
2023
Aron H. Blaesi, Nannaji Saka, Gastroretentive fibrous dosage forms for prolonged delivery of sparingly soluble tyrosine kinase inhibitors. Part 1: Dosage form design, and theoretical models of expansion, mechanical strength, and in vitro drug release, International Journal of Pharmaceutics, 2024, 124360. https://doi.org/10.1016/j.ijpharm.2024.124360
Aron H. Blaesi, Nannaji Saka, Gastroretentive fibrous dosage forms for prolonged delivery of sparingly soluble tyrosine kinase inhibitors. Part 2: Experimental validation of the models of expansion, mechanical strength, and in vitro drug release, International Journal of Pharmaceutics, 2024, 124361. https://doi.org/10.1016/j.ijpharm.2024.124361
Aron H. Blaesi, Nannaji Saka, Gastroretentive fibrous dosage forms for prolonged delivery of sparingly soluble tyrosine kinase inhibitors. Part 3: Theoretical models of drug concentration in blood, International Journal of Pharmaceutics, 2024, 124362. https://doi.org/10.1016/j.ijpharm.2024.124362
Aron H. Blaesi, Henning Richter, Nannaji Saka, Gastroretentive fibrous dosage forms for prolonged delivery of sparingly soluble tyrosine kinase inhibitors. Part 4: Experimental validation of the models of drug concentration in blood, International Journal of Pharmaceutics, 2024, 124363. https://doi.org/10.1016/j.ijpharm.2024.124363
2022
Aron H. Blaesi, Thomas Echtermann, Henning Richter, Nannaji Saka, The effect of a strengthening, semi-permeable fiber coating on the expansion, mechanical properties, and residence time of gastroretentive fibrous dosage forms, International Journal of Pharmaceutics 642, 2023, 122378. https://doi.org/10.1016/j.ijpharm.2022.122378
2021
Aron H. Blaesi, Dolf Kümmerlen, Henning Richter, and Nannaji Saka, Mechanical strength and gastric residence time of expandable fibrous dosage forms, International Journal of Pharmaceutics 613, 2022, 120792. https://doi.org/10.1016/j.ijpharm.2021.120792
Aron H. Blaesi, Nannaji Saka, Expandable, dual-excipient fibrous dosage forms for prolonged delivery of sparingly-soluble drugs, International Journal of Pharmaceutics and Biopharmaceutics, 615, 2022, 120396. https://doi.org/10.1016/j.ijpharm.2021.120396
2020
Aron H. Blaesi, Nannaji Saka, The role of excipient molecular weight in drug release by fibrous dosage forms with close packing and high drug loading, International Journal of Pharmaceutics, 606, 2021, 120009. https://doi.org/10.1016/j.ijpharm.2020.120009
2019
Aron H. Blaesi, Nannaji Saka, Expandable fibrous dosage forms for prolonged drug delivery, Materials Science and Engineering C, 120, 2021, 110144. https://doi.org/10.1016/j.msec.2019.110144
Aron H. Blaesi, Nannaji Saka, Solid-solution fibrous dosage forms for immediate delivery of sparingly soluble drugs: Part 2. 3D-micropatterned solid dosage forms, Materials Science and Engineering C, 129, 2021, 110211. https://doi.org/10.1016/j.msec.2019.110211
Aron H. Blaesi, Nannaji Saka, Solid-solution fibrous dosage forms for immediate delivery of sparingly soluble drugs: Part 1. Single fibers, Materials Science and Engineering C, 109, 2020, 109918. https://doi.org/10.1016/j.msec.2019.109918
2018
Aron H. Blaesi, Nannaji Saka, Fibrous dosage forms by wet 3D-micro-patterning: Process design, manufacture, and drug release rate, European Journal of Pharmaceutics and Biopharmaceutics, 130, 2018, 345-358. https://doi.org/10.1016/j.ejpb.2018.06.015
2017
Aron H. Blaesi, Nannaji Saka, 3D-micro-patterned fibrous dosage forms for immediate drug release, Materials Science and Engineering C, 84, 2018, 218-229. https://doi.org/10.1016/j.msec.2017.07.003
Aron H. Blaesi, Nannaji Saka, Continuous manufacture of polymeric cellular dosage forms, Chemical Engineering Journal, 320, 2017, 549-560. https://doi.org/10.1016/j.cej.2017.02.057
Aron H. Blaesi, Nannaji Saka, Microstructural effects in drug release by solid and cellular polymeric dosage forms: A comparative study, Materials Science and Engineering C, 80, 2017, 715-727. https://doi.org/10.1016/j.msec.2017.05.080
2016
Aron H. Blaesi, Nannaji Saka, Determination of the mechanical properties of solid and cellular polymeric dosage forms by diametral compression, International Journal of Pharmaceutics, 509, 2016, 444-453. https://doi.org/10.1016/j.ijpharm.2016.05.020
Aron H. Blaesi, Nannaji Saka, On the exfoliating polymeric cellular dosage forms for immediate drug release, European Journal of Pharmaceutics and Biopharmaceutics, 103, 2016, 210-218. https://doi.org/10.1016/j.ejpb.2016.03.032
2015
Aron H. Blaesi, Nannaji Saka, Melt-processed polymeric cellular dosage forms for immediate drug release, Journal of Controlled Release, 220, 2015, 397-405. https://doi.org/10.1016/j.jconrel.2015.10.046
Patents
Enzian’s technology is patented by more than 20 Patent applications and issued Patents. A list of selected United States Patents by year of issue is shown below.
2024
US 12,059,503 B2 titled “Method for the manufacture of solid dosage forms”.
2023
US 11,865,216 B2 titled “Expandable structured dosage form for immediate drug delivery”.
2022
US 11,478,427 B2 titled “Dosage form comprising structural framework of two-dimensional elements”.
US 11,285,116 B2 titled “Method for the manufacture of fibrous dosage forms”.
2021
US 11,129,798 B2 titled “Fibrous dosage form”.
2020
US 10,751,292 B2 titled “Method and apparatus for the manufacture of fibrous dosage forms”.
About Enzian
Enzian Pharmaceutics has emerged from the doctoral thesis of Dr. Aron H. Blaesi at the Massachusetts Institute of Technology (MIT). It was founded by Dr. Blaesi counseled by Dr. Nannaji Saka, also an MIT alumnus.
To achieve its mission, Enzian has a pharmaceutical laboratory in Zurich, Switzerland, for producing its dosage forms and testing them in vitro. Additionally, Enzian collaborates with University research laboratories and University hospitals (most notably at the University of Zurich, MIT, and Harvard Medical School) to validate the dosage forms in vitro, and in vivo in animals and in humans.
A short history of Enzian can be found here.
Technopark Zurich where Enzian has its laboratories.
Investment opportunities
Enzian is a fast-growing company on track to transform the design and manufacture of oral solid dosage forms.
We are currently seeking series A/B investors to conduct clinical trials, scale up manufacturing processes, and bring the gastroretentive dosage form to market.
For investment opportunities, please contact info@enzianpharma.com.
Aron H. Blaesi, Ph.D.
Dr. Blaesi is the founder and CEO of Enzian. He obtained his Bachelors and Masters degrees in Mechanical Engineering from ETH Zurich in 2007 and 2009, respectively, and a Ph.D. in Mechanical Engineering from the Massachusetts Institute of Technology (MIT) in 2014. After his Ph.D., while working on developing Enzian, Dr. Blaesi spent two years as a post-doctoral fellow in the laboratory of the late Dr. Warren M. Zapol at the Massachusetts General Hospital, Harvard Medical School. Since 2016 Dr. Blaesi has been working full-time on Enzian. He developed Enzian from scratch to the clinical-stage company it is now. He is the first inventor of fibrous dosage forms and more than twenty other patents and patent applications forming Enzian’s core technology. His work is widely published; he first-authored more than twenty peer-reviewed scientific publications. Lists of selected publications can be found on ResearchGate and Google Scholar.
Nannaji Saka, Sc.D.
Dr. Saka is the lead advisor to Enzian. He was graduated with a bachelor’s degree in Mechanical Engineering (in first class with honors) from Andhra University (India), with a master’s degree in Metallurgical Engineering from the Indian Institute of Technology/Kanpur (India), and with a doctoral degree in Materials Science and Engineering from MIT (Cambridge, MA). After graduating with a doctoral degree, Dr. Saka joined the Department of Mechanical Engineering at MIT as a post-doctoral fellow and was later promoted as a principal research scientist. Over the decades, he has published more than 100 technical papers, is an inventor on more than 20 patents, organized conferences, taught graduate and undergraduate courses, served as an advisor to scores of graduate and undergraduate students in their research, and advised several companies. A list of selected publications can be found on ResearchGate.